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Issue 21, 2011
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Multivalent interaction and selectivities in selectin binding of functionalized gold colloids decorated with carbohydrate mimetics

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Abstract

Colloidal gold particles with functionalized organic shells were applied as novel selectin binders. The ligand shell was terminated with different monocyclic carbohydrate mimetics as simplified analogs of the sLex unit found in biological selectin ligands. The multivalent presentation of the sulfated selectin binding epitopes on the gold particles led to extremely high binding affinities towards L- and P-selectin and IC50 values in the subnanomolar range. Depending on the ring size of the sulfated carbohydrate mimetic, its substitution pattern and its configuration, different selectivities for either L-selectin or P-selectin were obtained. These selectivities were not found for gold particles with simple acyclic sulfated alcohols, diols and triols in the ligand shell. In addition, the influence of the particle size and the thickness of the hydrophobic organic shell were systematically investigated.

Graphical abstract: Multivalent interaction and selectivities in selectin binding of functionalized gold colloids decorated with carbohydrate mimetics

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Supplementary files

Article information


Submitted
12 Apr 2011
Accepted
26 May 2011
First published
26 May 2011

Org. Biomol. Chem., 2011,9, 7448-7456
Article type
Paper

Multivalent interaction and selectivities in selectin binding of functionalized gold colloids decorated with carbohydrate mimetics

M. Roskamp, S. Enders, F. Pfrengle, S. Yekta, V. Dekaris, J. Dernedde, H. Reissig and S. Schlecht, Org. Biomol. Chem., 2011, 9, 7448
DOI: 10.1039/C1OB05583F

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