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Issue 1, 2011
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“Click-made” biaryl-linker improving efficiency in proteinlabelling for the membrane target protein of a bioactive compound

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Abstract

We report on the design, synthesis and assessment of a novel biaryl-linked (BArL) molecular probe for the exploration of low-abundant target proteins for bioactive compounds based on the activity based protein profiling (ABPP) approach. Surprisingly, the performance of the BArL probe was better than that of the stepwise tagging approach that is considered to be the most effective method used in ABPP study.

Graphical abstract: “Click-made” biaryl-linker improving efficiency in protein labelling for the membrane target protein of a bioactive compound

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Publication details

The article was received on 06 Oct 2010, accepted on 28 Oct 2010 and first published on 17 Nov 2010


Article type: Communication
DOI: 10.1039/C0OB00843E
Org. Biomol. Chem., 2011,9, 83-85

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    “Click-made” biaryl-linker improving efficiency in protein labelling for the membrane target protein of a bioactive compound

    Y. Nakamura, S. Inomata, M. Ebine, Y. Manabe, I. Iwakura and M. Ueda, Org. Biomol. Chem., 2011, 9, 83
    DOI: 10.1039/C0OB00843E

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