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Issue 2, 2011
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Conformationally rigid aromatic amino acids as potential building blocks for abiotic foldamers

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Abstract

This communication describes the development of conformationally constrained unnatural aromatic amino acids, constructed on rigid backbone wherein the carboxyl and amino groups project in two dimensions (planes) on the aromatic framework. Such a feature offers the possibility of design and development of conformationally ordered synthetic oligomers with intriguing structural architectures distinct from those classically observed. Furthermore, such amino acids will have the potential to extend the conformational space available for foldamer design with diverse backbone conformation and structural architectures.

Graphical abstract: Conformationally rigid aromatic amino acids as potential building blocks for abiotic foldamers

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Publication details

The article was received on 17 Aug 2010, accepted on 23 Oct 2010 and first published on 01 Nov 2010


Article type: Communication
DOI: 10.1039/C0OB00593B
Org. Biomol. Chem., 2011,9, 367-369

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    Conformationally rigid aromatic amino acids as potential building blocks for abiotic foldamers

    V. V. E. Ramesh, A. Roy, K. N. Vijayadas, A. M. Kendhale, P. Prabhakaran, R. Gonnade, V. G. Puranik and G. J. Sanjayan, Org. Biomol. Chem., 2011, 9, 367
    DOI: 10.1039/C0OB00593B

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