Issue 11, 2011

From synthetic to natural nanoparticles: monitoring the biodegradation of SPIO (P904) into ferritin by electron microscopy

Abstract

A strong focus on Superparamagnetic Iron Oxide Nanoparticles (SPIOs) has been appreciated recently especially for their use in Magnetic Resonance Imaging (MRI). However, some questions are being raised over these particles due to their long-term toxicity related to the production of toxic free iron during their biodegradation. Here we show by Electron Microscopy how SPIOs (P904) (Guerbet, Paris) are degraded after they are taken up by macrophages, so that iron from the SPIO core is progressively incorporated into the iron-storing protein ferritin (a nontoxic form of iron).

Graphical abstract: From synthetic to natural nanoparticles: monitoring the biodegradation of SPIO (P904) into ferritin by electron microscopy

Supplementary files

Article information

Article type
Communication
Submitted
31 Jul 2011
Accepted
16 Sep 2011
First published
11 Oct 2011

Nanoscale, 2011,3, 4597-4599

From synthetic to natural nanoparticles: monitoring the biodegradation of SPIO (P904) into ferritin by electron microscopy

J. D. López-Castro, A. V. Maraloiu, J. J. Delgado, J. J. Calvino, M.-G. Blanchin, N. Gálvez and J. M. Domínguez-Vera, Nanoscale, 2011, 3, 4597 DOI: 10.1039/C1NR10980D

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