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Issue 9, 2011
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Predicting and rationalizing the effect of surface charge distribution and orientation on nano-wire based FET bio-sensors

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Abstract

A single charge screening model of surface charge sensors in liquids (De Vico et al., Nanoscale, 2011, 3, 706–717) is extended to multiple charges to model the effect of the charge distributions of analyte proteins on FET sensor response. With this model we show that counter-intuitive signal changes (e.g. a positive signal change due to a net positive protein binding to a p-type conductor) can occur for certain combinations of charge distributions and Debye lengths. The new method is applied to interpret published experimental data on Streptavidin (Ishikawa et al., ACS Nano, 2009, 3, 3969–3976) and Nucleocapsid protein (Ishikawa et al., ACS Nano, 2009, 3, 1219–1224).

Graphical abstract: Predicting and rationalizing the effect of surface charge distribution and orientation on nano-wire based FET bio-sensors

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Article information


Submitted
25 Mar 2011
Accepted
19 May 2011
First published
03 Aug 2011

Nanoscale, 2011,3, 3635-3640
Article type
Paper

Predicting and rationalizing the effect of surface charge distribution and orientation on nano-wire based FET bio-sensors

L. De Vico, L. Iversen, M. H. Sørensen, M. Brandbyge, J. Nygård, K. L. Martinez and J. H. Jensen, Nanoscale, 2011, 3, 3635
DOI: 10.1039/C1NR10316D

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