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Issue 4, 2011
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Synthesis, functionalization and bioimaging applications of highly fluorescent carbon nanoparticles

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Abstract

Highly fluorescent crystalline carbon nanoparticles (CNPs) have been synthesized by one step microwave irradiation of sucrose with phosphoric acid at 100 W for 3 min 40 s. This method is very simple, rapid and economical and hence can be used for large scale applications. The average particle sizes are 3 to 10 nm and they emit bright green fluorescence under the irradiation of UV-light. Therefore, the particles can be used as a unique material for bioimaging as well as drug delivery. To further increase the fluorescence property of the synthetic carbon nanoparticles we simply functionalized them by using different organic dyes, such as fluorescein, rhodamine B and α-naphthylamine; the maximum fluorescence intensity was observed for the particles functionalized with fluorescein. It is very interesting to note that all of those compounds show maximum fluorescence intensity at 225 nm excitation wavelength and for any excitation wavelength the peak positions are exactly same the position as that of CNPs itself, which is completely different from the individual precursors (dyes). All of the above compounds, including CNPs, have also been successfully introduced into the erythrocyte enriched fraction of healthy human blood cells with minimum cytotoxicity.

Graphical abstract: Synthesis, functionalization and bioimaging applications of highly fluorescent carbon nanoparticles

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Publication details

The article was received on 01 Oct 2010, accepted on 17 Nov 2010 and first published on 03 Feb 2011


Article type: Paper
DOI: 10.1039/C0NR00735H
Nanoscale, 2011,3, 1533-1540

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    Synthesis, functionalization and bioimaging applications of highly fluorescent carbon nanoparticles

    S. Chandra, P. Das, S. Bag, D. Laha and P. Pramanik, Nanoscale, 2011, 3, 1533
    DOI: 10.1039/C0NR00735H

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