Jump to main content
Jump to site search

Issue 7, 2011
Previous Article Next Article

The regulation of the secondary metabolism of Streptomyces: new links and experimental advances

Author affiliations

Abstract

Covering: up to early 2011

Streptomycetes and other actinobacteria are renowned as a rich source of natural products of clinical, agricultural and biotechnological value. They are being mined with renewed vigour, supported by genome sequencing efforts, which have revealed a coding capacity for secondary metabolites in vast excess of expectations that were based on the detection of antibiotic activities under standard laboratory conditions. Here we review what is known about the control of production of so-called secondary metabolites in streptomycetes, with an emphasis on examples where details of the underlying regulatory mechanisms are known. Intriguing links between nutritional regulators, primary and secondary metabolism and morphological development are discussed, and new data are included on the carbon control of development and antibiotic production, and on aspects of the regulation of the biosynthesis of microbial hormones. Given the tide of antibiotic resistance emerging in pathogens, this review is peppered with approaches that may expand the screening of streptomycetes for new antibiotics by awakening expression of cryptic antibiotic biosynthetic genes. New technologies are also described that have potential to greatly further our understanding of gene regulation in what is an area fertile for discovery and exploitation.

Graphical abstract: The regulation of the secondary metabolism of Streptomyces: new links and experimental advances

Back to tab navigation

Publication details

The article was received on 13 Jan 2011 and first published on 25 May 2011


Article type: Review Article
DOI: 10.1039/C1NP00003A
Nat. Prod. Rep., 2011,28, 1311-1333

  •   Request permissions

    The regulation of the secondary metabolism of Streptomyces: new links and experimental advances

    G. P. van Wezel and K. J. McDowall, Nat. Prod. Rep., 2011, 28, 1311
    DOI: 10.1039/C1NP00003A

Search articles by author

Spotlight

Advertisements