Jump to main content
Jump to site search

Issue 12, 2011
Previous Article Next Article

Combination of PAGE and LA-ICP-MS as an analytical workflow in metallomics: state of the art, new quantification strategies, advantages and limitations

Author affiliations

Abstract

Metallomics (more specifically, metalloproteomics) is an emerging field that encompasses the role, uptake, transport and storage of trace metals, which are essential to preserve the functions of proteins within a biological system. The current strategies for metal-binding and metalloprotein analysis based on the combination of polyacrylamide gel electrophoresis (PAGE) and laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) are discussed in this review. The advantages, limitations and the most recently developed and applied quantification approaches for this methodology are also described.

Graphical abstract: Combination of PAGE and LA-ICP-MS as an analytical workflow in metallomics: state of the art, new quantification strategies, advantages and limitations

Back to tab navigation

Article information


Submitted
26 Jul 2011
Accepted
10 Oct 2011
First published
24 Oct 2011

Metallomics, 2011,3, 1271-1279
Article type
Critical Review

Combination of PAGE and LA-ICP-MS as an analytical workflow in metallomics: state of the art, new quantification strategies, advantages and limitations

A. Sussulini and J. S. Becker, Metallomics, 2011, 3, 1271
DOI: 10.1039/C1MT00116G

Social activity

Search articles by author

Spotlight

Advertisements