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Issue 11, 2011

Role of metal ions in aggregation of intrinsically disordered proteins in neurodegenerative diseases

Author affiliations

Abstract

Neurodegenerative diseases constitute a set of pathological conditions originating from the slow, irreversible, and systematic cell loss within the various regions of the brain and/or the spinal cord. Depending on the affected region, the outcomes of the neurodegeneration are very broad and diverse, ranging from the problems with movements to dementia. Some neurodegenerative diseases are associated with protein misfolding and aggregation. Many proteins that misfold in human neurodegenerative diseases are intrinsically disordered; i.e., they lack a stable tertiary and/or secondary structure under physiological conditions in vitro. These intrinsically disordered proteins (IDPs) functionally complement ordered proteins, being typically involved in regulation and signaling. There is accumulating evidence that altered metal homeostasis may be related to the progression of neurodegenerative diseases. This review examines the effects of metal ion binding on the aggregation pathways of IDPs found in neurodegenerative diseases.

Graphical abstract: Role of metal ions in aggregation of intrinsically disordered proteins in neurodegenerative diseases

Article information


Submitted
18 Jul 2011
Accepted
05 Aug 2011
First published
25 Aug 2011

Metallomics, 2011,3, 1163-1180
Article type
Critical Review

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