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Issue 11, 2011
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Chromate toxicity and the role of sulfur

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The molecular mode(s)-of-action of the toxic metal chromium has yet to be fully resolved. This Mini review focuses on interactions between chromate and sulfur in biological systems. Cr binds sulfur ligands, with cysteine and glutathione having the capacity to aggravate or ameliorate Cr toxicity. Competition between chromate and sulfate for uptake and in metabolism provokes sulfur starvation, which can be growth limiting. Recent data indicate that sulfur deficiency determines protein damage-related Cr toxicity, due to mRNA mistranslation caused by Cr-induced S limitation. Sulfur deprivation could contribute to additional aspects of Cr toxicity, including oxidative DNA damage and Cr related disease.

Graphical abstract: Chromate toxicity and the role of sulfur

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The article was received on 31 May 2011, accepted on 23 Jun 2011 and first published on 01 Aug 2011

Article type: Minireview
DOI: 10.1039/C1MT00059D
Metallomics, 2011,3, 1119-1123

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    Chromate toxicity and the role of sulfur

    S. L. Holland and S. V. Avery, Metallomics, 2011, 3, 1119
    DOI: 10.1039/C1MT00059D

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