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Issue 6, 2011
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FAB, ESI and MALDI Mass Spectrometric methods in the study of metallo-drugs and their biomolecular interactions

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Abstract

This review surveys the soft ionisation mass spectrometric methods that are most commonly used for the investigation of the mechanism of interaction between metallo-drugs and biomolecules. In the first part of the review, an overview of the applications of transition metal complexes in the therapy of various diseases (arthritis, cancer, diabetes) is given, whereas the second part focuses on the obtained results dealing with various aspects of the interaction between metal complexes and different types of biomolecules. Possibilities and limitations of each mass spectrometric method—namely, fast atom bombardment (FAB), electrospray ionisation (ESI) and matrix-assisted laser desorption and ionisation (MALDI)—are discussed in the third part of this review along with the examples of their application for the analysis of metal complexes, as well as of the products of their interaction with biomolecules.

Graphical abstract: FAB, ESI and MALDI Mass Spectrometric methods in the study of metallo-drugs and their biomolecular interactions

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Publication details

The article was received on 06 Dec 2010, accepted on 01 Mar 2011 and first published on 11 Apr 2011


Article type: Critical Review
DOI: 10.1039/C0MT00096E
Metallomics, 2011,3, 550-565

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    FAB, ESI and MALDI Mass Spectrometric methods in the study of metallo-drugs and their biomolecular interactions

    M. Petković and T. Kamčeva, Metallomics, 2011, 3, 550
    DOI: 10.1039/C0MT00096E

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