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Issue 3, 2011
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Insights from Caenorhabditis elegans on the role of metals in neurodegenerative diseases

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Abstract

Neurodegeneration is characterized by the cell death or loss of structure and/or function of neurons. Many neurodegenerative diseases including Parkinson's disease (PD) and Alzheimer's disease (AD) are the result of neurodegenerative processes. Metals are essential for many life processes, but they are also culpable for several neurodegenerative mechanisms. In this review, we discuss the role of metals in neurodegenerative diseases with emphasis on the utility of Caenorhabditis elegans (C. elegans) genetic models in deciphering mechanisms associated with the etiology of PD and AD.

Graphical abstract: Insights from Caenorhabditis elegans on the role of metals in neurodegenerative diseases

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Article information


Submitted
23 Oct 2010
Accepted
15 Dec 2010
First published
06 Jan 2011

Metallomics, 2011,3, 271-279
Article type
Minireview

Insights from Caenorhabditis elegans on the role of metals in neurodegenerative diseases

E. J. Martinez-Finley, D. S. Avila, S. Chakraborty and M. Aschner, Metallomics, 2011, 3, 271
DOI: 10.1039/C0MT00064G

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