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Issue 6, 2011
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Synthesis and efficient siRNA delivery of polyamine-conjugated cationic nucleoside lipids

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Abstract

To advance their use as nonviral gene delivery agents, we have synthesized cationic nucleoside lipids featuring naturally occurring polyamines conjugated at the 5′ position and oleyl groups at the 2′ and 3′ positions of uridine, through chemically stable, but biodegradable, carbamate linkers. The corresponding lipoplexes are efficient and nontoxic vectors for the delivery of siRNA into cells in vitro.

Graphical abstract: Synthesis and efficient siRNA delivery of polyamine-conjugated cationic nucleoside lipids

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Publication details

The article was received on 18 Jan 2011, accepted on 11 Mar 2011 and first published on 07 Apr 2011


Article type: Concise Article
DOI: 10.1039/C1MD00014D
Med. Chem. Commun., 2011,2, 505-508

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    Synthesis and efficient siRNA delivery of polyamine-conjugated cationic nucleoside lipids

    S. P. Patil, J. W. Yi, E. Bang, E. M. Jeon and B. H. Kim, Med. Chem. Commun., 2011, 2, 505
    DOI: 10.1039/C1MD00014D

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