Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 3, 2011
Previous Article Next Article

The discovery of a novel prototype small molecule TLR7 agonist for the treatment of hepatitis C virus infection

Author affiliations

Abstract

A series of heterocycle analogues of an adenine template were explored for TLR7 agonist potency and pharmacokinetics. One compound was identified with an excellent pharmacokinetic, in vitro potency and in vivo interferon induction profile in a mouse model, and was selected for further pre-clinical evaluation as a potential treatment for hepatitis C viral infection.

Graphical abstract: The discovery of a novel prototype small molecule TLR7 agonist for the treatment of hepatitis C virus infection

Back to tab navigation

Supplementary files

Article information


Submitted
01 Nov 2010
Accepted
03 Dec 2010
First published
20 Dec 2010

Med. Chem. Commun., 2011,2, 185-189
Article type
Concise Article

The discovery of a novel prototype small molecule TLR7 agonist for the treatment of hepatitis C virus infection

D. C. Pryde, T. Tran, P. Jones, G. C. Parsons, G. Bish, F. M. Adam, M. C. Smith, D. S. Middleton, N. N. Smith, F. Calo, D. Hay, M. Paradowski, K. J. W. Proctor, T. Parkinson, C. Laxton, D. N. A. Fox, N. J. Horscroft, G. Ciaramella, H. M. Jones, J. Duckworth, N. Benson, A. Harrison and R. Webster, Med. Chem. Commun., 2011, 2, 185
DOI: 10.1039/C0MD00197J

Search articles by author

Spotlight

Advertisements