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Issue 3, 2011
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Synthesis and anti HSV-1 evaluation of novel indole-3,4-diones

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Abstract

A novel class of water soluble indole-3,4-diones has been synthesized and evaluated in vitro for antiviral activity against HSV-1. The results showed lack of cytotoxicity and significant antiviral activity. The cellular internalization efficiency and the antiherpetic effect were successfully increased by incorporation into nanoaggregates of an amphiphilic β-cyclodextrin.

Graphical abstract: Synthesis and anti HSV-1 evaluation of novel indole-3,4-diones

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Article information


Submitted
27 Oct 2010
Accepted
02 Dec 2010
First published
20 Dec 2010

Med. Chem. Commun., 2011,2, 172-175
Article type
Concise Article

Synthesis and anti HSV-1 evaluation of novel indole-3,4-diones

A. Scala, M. Cordaro, A. Mazzaglia, F. Risitano, A. Venuti, M. T. Sciortino and G. Grassi, Med. Chem. Commun., 2011, 2, 172
DOI: 10.1039/C0MD00190B

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