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Issue 10, 2011
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Are pyridazines privileged structures?

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Abstract

One can estimate that about 50% of all the drug molecules used in medicine contain a phenyl ring which can be substituted or not. The bioisosteric replacement of these phenyl rings by the corresponding pyridazine rings opens an access to several thousands of diaza analogues presenting more interaction possibilities, lower Log P values and improved crystalline salts. The use of pyridazine scaffolds in place of phenyl scaffolds entails additional interaction possibilities. Another interest of pyridazines is their capacity to act as original functional surrogates. Thus, aminopyridazines can be used as carboxamide, as well as amine surrogates. Finally, the many examples of pyridazines used either as a structural element or as a main scaffold, justify largely their status as privileged structures

Graphical abstract: Are pyridazines privileged structures?

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Publication details

The article was received on 15 Mar 2011, accepted on 17 Apr 2011 and first published on 10 Jun 2011


Article type: Review Article
DOI: 10.1039/C1MD00074H
Med. Chem. Commun., 2011,2, 935-941

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    Are pyridazines privileged structures?

    C. G. Wermuth, Med. Chem. Commun., 2011, 2, 935
    DOI: 10.1039/C1MD00074H

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