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Issue 12, 2011
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Potential atypical antipsychotics: synthesis, binding affinity and SAR of new heterocyclic bioisosteric butyrophenone analogues as multitarget ligands

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Abstract

A series of 15 heterocyclic butyrophenone analogues was synthesized as potential multi-target ligands. The compounds were assayed for their in vitro human D2 and 5-HT2A receptor affinity, and those compounds exhibiting the highest affinities were evaluated for binding affinity on D1, D3, 5-HT1A, 5-HT2C and 5-HT6 receptors.

Graphical abstract: Potential atypical antipsychotics: synthesis, binding affinity and SAR of new heterocyclic bioisosteric butyrophenone analogues as multitarget ligands

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Publication details

The article was received on 06 Aug 2011, accepted on 12 Sep 2011 and first published on 11 Oct 2011


Article type: Concise Article
DOI: 10.1039/C1MD00202C
Med. Chem. Commun., 2011,2, 1194-1200

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    Potential atypical antipsychotics: synthesis, binding affinity and SAR of new heterocyclic bioisosteric butyrophenone analogues as multitarget ligands

    M. Barceló, E. Raviña, M. J. Varela, J. Brea, M. I. Loza and C. F. Masaguer, Med. Chem. Commun., 2011, 2, 1194
    DOI: 10.1039/C1MD00202C

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