Jump to main content
Jump to site search

Issue 10, 2011
Previous Article Next Article

Discovery of CP-866,087, a mu opioid receptor antagonist for the treatment of alcohol abuse and dependence

Author affiliations

Abstract

CP-866,087 (compound 15) is a novel, potent and selective mu opioid receptor antagonist. The design rationale, synthesis, in vitro and in vivo biological evaluation are reported herein. Preclinical efficacy data in disease relevant models measuring reduction of alcohol intake are presented, along with preclinical pharmacokinetic properties which supported the selection of the title compound for clinical evaluation.

Graphical abstract: Discovery of CP-866,087, a mu opioid receptor antagonist for the treatment of alcohol abuse and dependence

Back to tab navigation

Supplementary files

Publication details

The article was received on 23 Jun 2011, accepted on 27 Jul 2011 and first published on 25 Aug 2011


Article type: Concise Article
DOI: 10.1039/C1MD00164G
Med. Chem. Commun., 2011,2, 1001-1005

  •   Request permissions

    Discovery of CP-866,087, a mu opioid receptor antagonist for the treatment of alcohol abuse and dependence

    S. F. McHardy, S. D. Heck, S. Guediche, M. Kalman, M. P. Allen, M. Tu, D. K. Bryce, A. W. Schmidt, M. Vanase-Frawley, E. Callegari, S. Doran, N. J. Grahame, S. McLean and S. Liras, Med. Chem. Commun., 2011, 2, 1001
    DOI: 10.1039/C1MD00164G

Search articles by author

Spotlight

Advertisements