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Issue 11, 2011
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Synthesis and evaluation of novel 5-sulfonyl-indolin-2-ones as potent cytotoxic agents

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Abstract

A series of novel 5-sulfonyl-indolin-2-ones were designed, synthesized, and screened for their antitumor activity on SGC-7901, A549, HCT116, and ECA-109 cell lines. Four compounds with the most potent antitumor activity were further determined as fibroblast growth factor receptor 2 (FGFR2) inhibitors. Among them, compound 2b was further identified to inhibit HUVECs tube formation.

Graphical abstract: Synthesis and evaluation of novel 5-sulfonyl-indolin-2-ones as potent cytotoxic agents

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Publication details

The article was received on 20 Apr 2011, accepted on 06 Aug 2011 and first published on 07 Sep 2011


Article type: Concise Article
DOI: 10.1039/C1MD00105A
Med. Chem. Commun., 2011,2, 1054-1057

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    Synthesis and evaluation of novel 5-sulfonyl-indolin-2-ones as potent cytotoxic agents

    Y. Luo, F. Xiao, S. Qian, Q. He, W. Lu and B. Yang, Med. Chem. Commun., 2011, 2, 1054
    DOI: 10.1039/C1MD00105A

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