Synthesis and evaluation of novel 5-sulfonyl-indolin-2-ones as potent cytotoxic agents†
Abstract
A series of novel 5-sulfonyl-indolin-2-ones were designed, synthesized, and screened for their antitumor activity on SGC-7901, A549, HCT116, and ECA-109 cell lines. Four compounds with the most potent antitumor activity were further determined as fibroblast growth factor receptor 2 (FGFR2)