Issue 4, 2011
From the journal:

MedChemComm

New insight into the mode of action of vancomycin dimers in bacterial cell wall synthesis†

Osamu Yoshida,b   Jun Nakamura,a   Hidenori Yamashiro,b   Kenji Miura,b   Sayaka Hayashi,a   Kosei Umetsu,a   Shu Xu,a   Hideki Maki*b  and  Hirokazu Arimoto*a  

* Corresponding authors

a Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Sendai, Japan
E-mail: arimoto@biochem.tohoku.ac.jp
Fax: +81-(0)22-217-6204
Tel: +81-(0)22-217-6201

b Discovery Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan
E-mail: hideki.maki@shionogi.co.jp

Abstract

The emergence of vancomycin-resistant bacteria has created an urgent need for new active analogues of vancomycin. We previously reported vancomycin dimers with in vivo antibacterial activity. Here, we provide the first experimental insights into their inhibitory actions in bacterial cell wall synthesis.

Graphical abstract: New insight into the mode of action of vancomycin dimers in bacterial cell wall synthesis

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Article information

DOI
https://doi.org/10.1039/C0MD00230E
Article type
Concise Article
Submitted
19 Nov 2010
Accepted
16 Jan 2011
First published
11 Feb 2011

Med. Chem. Commun., 2011,2, 278-282

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New insight into the mode of action of vancomycin dimers in bacterial cell wall synthesis

O. Yoshida, J. Nakamura, H. Yamashiro, K. Miura, S. Hayashi, K. Umetsu, S. Xu, H. Maki and H. Arimoto, Med. Chem. Commun., 2011, 2, 278 DOI: 10.1039/C0MD00230E

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