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Issue 6, 2011
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Synthesis and biological evaluation of tetrazole containing compounds as possible anticancer agents

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Abstract

A series of new tetrazole derivatives are synthesized from Baylis–Hillman allyl amines in a clean, efficient and straightforward manner. The stereochemistry of the double bond is confirmed by X-ray diffraction data. These compounds are evaluated for in vitro anticancer activity against five cancer cell lines. Most of the compounds exhibited good anticancer activity in micro molar concentration out of 16 compounds synthesized and screened. Furthermore, the compound 5o has good binding affinity to calf thymus DNA (ct DNA), as assayed by UV-vis absorption and fluorescence spectroscopic methods.

Graphical abstract: Synthesis and biological evaluation of tetrazole containing compounds as possible anticancer agents

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Publication details

The article was received on 15 Dec 2010, accepted on 01 Mar 2011 and first published on 29 Mar 2011


Article type: Concise Article
DOI: 10.1039/C0MD00263A
Med. Chem. Commun., 2011,2, 486-492

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    Synthesis and biological evaluation of tetrazole containing compounds as possible anticancer agents

    C. N. S. S. P. Kumar, D. K. Parida, A. Santhoshi, A. K. Kota, B. Sridhar and V. J. Rao, Med. Chem. Commun., 2011, 2, 486
    DOI: 10.1039/C0MD00263A

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