Issue 3, 2011

Interactions of polysulfanes with components of red blood cells

Abstract

Traditionally, the activity of most polysulfanes has been associated with the redox behaviour of the sulfur-sulfur bond. Here we show that polysulfanes, such as diallyltri- and tetrasulfide, also interact with cellular membranes and certain metalloproteins. Together, multiple interactions with various biological targets may explain best the biological activity of such compounds.

Graphical abstract: Interactions of polysulfanes with components of red blood cells

Supplementary files

Article information

Article type
Concise Article
Submitted
04 Nov 2010
Accepted
11 Dec 2010
First published
19 Jan 2011

Med. Chem. Commun., 2011,2, 196-200

Interactions of polysulfanes with components of red blood cells

T. Schneider, L. A. Ba, K. Khairan, C. Zwergel, N. D. Bach, I. Bernhardt, W. Brandt, L. Wessjohann, M. Diederich and C. Jacob, Med. Chem. Commun., 2011, 2, 196 DOI: 10.1039/C0MD00203H

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