Issue 2, 2011
From the journal:

MedChemComm

Biological evaluation of imidazolium- and ammonium-based salts as HIV-1 integrase inhibitors

Kasthuraiah Maddali,†a   Vineet Kumar,†b   Christophe Marchand,a   Yves Pommier*a  and  Sanjay V. Malhotra*b  

* Corresponding authors

a Laboratory of molecular pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
E-mail: pommier@nih.gov
Tel: +1-301-496-5944

b Laboratory of Synthetic Chemistry, SAIC Frederick Inc., National Cancer Institute at Frederick, 1050 Boyles St., Frederick, MD, USA
E-mail: malhotrasa@mail.nih.gov
Tel: +1-301-846-5141

Abstract

Ammonium- and imidazolium-based ionic salts were studied for their application as inhibitors of HIV-1 integrase (IN). These compounds were active in the inhibition of both the 3′-processing (3′-P) and strand transfer (ST) steps of the integration reaction. A correlation of activity with chain length of the alkyl substituent in both classes of ionic salts was observed.

Graphical abstract: Biological evaluation of imidazolium- and ammonium-based salts as HIV-1 integrase inhibitors

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Article information

DOI
https://doi.org/10.1039/C0MD00201A
Article type
Concise Article
Submitted
03 Nov 2010
Accepted
25 Nov 2010
First published
20 Dec 2010

Med. Chem. Commun., 2011,2, 143-150

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Biological evaluation of imidazolium- and ammonium-based salts as HIV-1 integrase inhibitors

K. Maddali, V. Kumar, C. Marchand, Y. Pommier and S. V. Malhotra, Med. Chem. Commun., 2011, 2, 143 DOI: 10.1039/C0MD00201A

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