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Issue 9, 2011
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Photochemical control of bacterial signal processing using a light-activated erythromycin

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Abstract

Bacterial cells control resistance to the macrolide antibiotic erythromycin using the MphR(A) repressor protein. Erythromycin binds to MphR(A), causing release of the PmphR promoter, activating expression of the 2′-phosphotransferase Mph(A). We engineered the MphR(A)/promoter system to, in conjunction with a light-activatable derivative of erythromycin, enable photochemical activation of gene expression in E. coli. We applied this photochemical gene switch to the construction of a light-triggered logic gate, a light-controlled band-pass filter, as well as spatial and temporal control of gene expression.

Graphical abstract: Photochemical control of bacterial signal processing using a light-activated erythromycin

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Supplementary files

Article information


Submitted
04 May 2011
Accepted
11 Jul 2011
First published
22 Jul 2011

Mol. BioSyst., 2011,7, 2554-2557
Article type
Communication

Photochemical control of bacterial signal processing using a light-activated erythromycin

L. Gardner, Y. Zou, A. Mara, T. A. Cropp and A. Deiters, Mol. BioSyst., 2011, 7, 2554
DOI: 10.1039/C1MB05166K

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