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Issue 9, 2011
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Regulation of integrins by conformation and traffic: it takes two to tango

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Abstract

In multicellular organisms, the execution of complex morphogenetic events, such as gastrulation or vascular morphogenesis, depends on the dynamic modulation of adhesion. Guidance cues, such as chemokines, growth factors, and semaphorins control the attachment of cells to extracellular matrix proteins by regulating the conformational activation of integrin receptors. The endo–exocytic traffic of integrins back and forth from the plasma membrane represents another crucial regulatory aspect in cell adhesion and motility. Recent work added an additional layer of complexity by indicating that distinct molecular machineries are required for trafficking active and inactive integrins.

Graphical abstract: Regulation of integrins by conformation and traffic: it takes two to tango

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Publication details

The article was received on 18 Feb 2011, accepted on 23 Jun 2011 and first published on 15 Jul 2011


Article type: Review Article
DOI: 10.1039/C1MB05066D
Mol. BioSyst., 2011,7, 2539-2546

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    Regulation of integrins by conformation and traffic: it takes two to tango

    D. Valdembri, C. Sandri, M. Santambrogio and G. Serini, Mol. BioSyst., 2011, 7, 2539
    DOI: 10.1039/C1MB05066D

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