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Issue 15, 2011
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A Teflon microreactor with integrated piezoelectric actuator to handle solid forming reactions

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Abstract

We present a general inexpensive method for realizing a Teflon stack microreactor with an integrated piezoelectric actuator for conducting chemical synthesis with solid products. The microreactors are demonstrated with palladium-catalyzed C–N cross-coupling reactions, which are prone to clogging microchannels by forming insoluble salts as by-products. Investigations of the ultrasonic waveform applied by the piezoelectric actuator reveal an optimal value of 50 kHz at a load power of 30 W. Operating the system at these conditions, the newly developed Teflon microreactor handles the insoluble solids formed and no clogging is observed. The investigated reactions reach full conversion in very short reaction times and high isolated yields are obtained (>95% yield).

Graphical abstract: A Teflon microreactor with integrated piezoelectric actuator to handle solid forming reactions

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Supplementary files

Article information


Submitted
21 Apr 2011
Accepted
26 May 2011
First published
23 Jun 2011

Lab Chip, 2011,11, 2488-2492
Article type
Paper

A Teflon microreactor with integrated piezoelectric actuator to handle solid forming reactions

S. Kuhn, T. Noël, L. Gu, P. L. Heider and K. F. Jensen, Lab Chip, 2011, 11, 2488
DOI: 10.1039/C1LC20337A

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