Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 4, 2011
Previous Article Next Article

EIS microfluidic chips for flow immunoassay and ultrasensitive cholera toxin detection

Author affiliations

Abstract

A flow-injection impedimetric immunosensor for the sensitive, direct and label-free detection of cholera toxin is reported. A limit of detection smaller than 10 pM was achieved, a value thousands of times lower than the lethal dose. The developed chips fulfil the requirement of low cost and quick reply of the assay and are expected to enable field screening, prompt diagnosis and medical intervention without the need of specialized personnel and expensive equipment, a perspective of special relevance for use in developing countries. Since the chip layout includes two sensing areas each one with a 2 × 2 sensor array, our biochips can allow statistical or (alternatively) multiplex analysis of biorecognition events between antibodies immobilized on each working electrode and different antigens flowing into the chamber.

Graphical abstract: EIS microfluidic chips for flow immunoassay and ultrasensitive cholera toxin detection

Back to tab navigation

Article information


Submitted
14 Sep 2010
Accepted
29 Oct 2010
First published
03 Dec 2010

Lab Chip, 2011,11, 658-663
Article type
Paper

EIS microfluidic chips for flow immunoassay and ultrasensitive cholera toxin detection

M. S. Chiriacò, E. Primiceri, E. D'Amone, R. E. Ionescu, R. Rinaldi and G. Maruccio, Lab Chip, 2011, 11, 658
DOI: 10.1039/C0LC00409J

Social activity

Search articles by author

Spotlight

Advertisements