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Issue 16, 2011
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DNA tracking within a nanochannel: device fabrication and experiments

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Abstract

Fabrication of nanochannels is drawing considerable interest due to its broad applications in nanobiotechnology (e.g. biomolecular sensing and single DNA manipulation). Nanochannels offer distinct advantages in allowing a slower translocation and multiple sensing spots along the channel, both of which improve the read-out resolution. However, implementing electrodes inside the nanochannel has rarely been demonstrated to our knowledge. The device described in this work is a Si–Glass anodically bonded Lab-on-a-Chip (LOC) device of a few millimetres in size capable of performing DNA manipulation. The LOC device structure is based on two mainstream microchannels interconnected by nanochannels. DNA, once trapped within the nanochannel, has been tracked throughout the length of the channel and the data have been recorded and analysed.

Graphical abstract: DNA tracking within a nanochannel: device fabrication and experiments

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Publication details

The article was received on 27 Jan 2011, accepted on 02 Jun 2011 and first published on 06 Jul 2011


Article type: Paper
DOI: 10.1039/C1LC20075E
Lab Chip, 2011,11, 2711-2719

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    DNA tracking within a nanochannel: device fabrication and experiments

    V. R. S. S. Mokkapati, V. Di Virgilio, C. Shen, J. Mollinger, J. Bastemeijer and A. Bossche, Lab Chip, 2011, 11, 2711
    DOI: 10.1039/C1LC20075E

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