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Issue 4, 2011
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Lab-on-a-chip based immunosensor principles and technologies for the detection of cardiac biomarkers: a review

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Abstract

This review examines the current state of the art lab-on-a-chip and microfluidic based biosensor technologies used in the detection of cardiac biomarkers. The determination and quantification of blood based, cardiac biomarkers are crucial in the triage and management of a range of cardiac related conditions, where time delay has a major impact on short and longer-term outcomes of a patient. The design and manufacturing of biomarker detection systems are multi-disciplinary in nature and require researchers to have knowledge of both life sciences and engineering for the full potential of this field to be realised. This review will therefore provide a comprehensive overview of chip based immunosensing technology as applied to cardiac biomarker detection, while discussing the potential suitability and limitations of each configuration for incorporation within a clinical diagnostics device suitable for point-of-care applications.

Graphical abstract: Lab-on-a-chip based immunosensor principles and technologies for the detection of cardiac biomarkers: a review

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Article information


Submitted
15 Jul 2010
Accepted
04 Nov 2010
First published
23 Dec 2010

Lab Chip, 2011,11, 569-595
Article type
Tutorial Review

Lab-on-a-chip based immunosensor principles and technologies for the detection of cardiac biomarkers: a review

M. Mohammed and M. P. Y. Desmulliez, Lab Chip, 2011, 11, 569
DOI: 10.1039/C0LC00204F

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