Issue 36, 2011
From the journal:

Journal of Materials Chemistry

Programmable DNA switch for bioresponsive controlled release

Linfeng Chen,a   Yongqiang Wen,*a   Bin Su,a   Jiancheng Di,b   Yanlin Song*a  and  Lei Jianga  

* Corresponding authors

a Beijing National Laboratory for Molecular Sciences (BNLMS), Key Lab of Organic Solids, Laboratory of New Materials, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China
E-mail: ylsong@iccas.ac.cn, wyq_wen@iccas.ac.cn

b China and State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun, China

Abstract

A bioresponsive controlled release system based on mesoporous silica nanoparticles (MS) was designed and constructed. Through the DNAa/DANb assembly, DNAb-modified gold nanoparticles (AuNPs-DNAb) could be attached to the pores of MS covalently functionalized with DNAa. In the presence of adenosine, the pores of MS could be opened and the encapsulated guest was released, due to the interaction between DNAb and adenosine. Förster resonance energy transfer (FRET) was used to confirm the switching mechanism. Furthermore, the carry system was exclusively responsive to adenosine, and the process was dependent on the concentration of adenosine, which made the system promising for target-directing controlled release.

Graphical abstract: Programmable DNA switch for bioresponsive controlled release

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Article information

DOI
https://doi.org/10.1039/C1JM12203G
Article type
Paper
Submitted
18 May 2011
Accepted
26 May 2011
First published
08 Jul 2011

J. Mater. Chem., 2011,21, 13811-13816

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Programmable DNA switch for bioresponsive controlled release

L. Chen, Y. Wen, B. Su, J. Di, Y. Song and L. Jiang, J. Mater. Chem., 2011, 21, 13811 DOI: 10.1039/C1JM12203G

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