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Issue 14, 2011
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Uniform hollow mesoporous silicananocages for drug delivery in vitro and in vivo for liver cancer therapy

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Abstract

In this article, we report the fabrication of monodisperse hollow mesoporous silica (HMS) nanocages with uniform size possessing a hollow cubic core and mesoporous shell with penetrating pore channels based on a template-coating-etching process. It is worthwhile noting the obtained HMS nanocages with cubic void space and highly porous shell endow the structures with much higher storage capacity and sustained release of anticancer drugs. More importantly, the therapeutic efficacy of doxorubicin-loaded HMS nanocages was evaluated in vitro and in vivo for liver cancer therapy. The results show that the doxorubicin-loaded HMS nanocages have good cell uptake and can induce efficient cell deathinvitro. Taken together, this study demonstrates that the biocompatible HMS nanocages can effectively deliver drugs to the tumors and suppress tumor growth compared to free doxorubicinin vivo. Additionally, the synthetic strategy has also extended to fabrication of the uniform and monodisperse HMS nanocapsules with spherical shape.

Graphical abstract: Uniform hollow mesoporous silica nanocages for drug delivery in vitro and in vivo for liver cancer therapy

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Publication details

The article was received on 27 Nov 2010, accepted on 12 Jan 2011 and first published on 18 Feb 2011


Article type: Paper
DOI: 10.1039/C0JM04115G
J. Mater. Chem., 2011,21, 5299-5306

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    Uniform hollow mesoporous silica nanocages for drug delivery in vitro and in vivo for liver cancer therapy

    T. Wang, F. Chai, Q. Fu, L. Zhang, H. Liu, L. Li, Y. Liao, Z. Su, C. Wang, B. Duan and D. Ren, J. Mater. Chem., 2011, 21, 5299
    DOI: 10.1039/C0JM04115G

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