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Issue 21, 2011
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Functionalization of upconverted luminescent NaYF4 : Yb/Er nanocrystals by folic acidchitosan conjugates for targeted lung cancer cell imaging

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Abstract

We demonstrate a robust approach to functionalize the upconverted luminescent NaYF4:Yb/Er nanocrystals with folic acid (FA)–chitosan conjugates for specific targeting and imaging of lung cancer cells. In this approach, the amine groups of FAchitosan conjugates covalently reacted with the carboxyl groups located on the surface of dimercaptosuccinic acid (DMSA)-modified NaYF4 : Yb/Er nanoparticles. The produced FAchitosan-coated NaYF4 : Yb/Er nanoparticles were characterized by means of transmission electron microscopy (TEM) and Fourier transform infrared (FTIR) and photoluminescence (PL) spectroscopy. Additionally, a cell viability assay showed that those FAchitosan-coated fluorescence nanocrystals were fully biocompatible. Moreover, confocal fluorescence images illustrated that the functionalized-NaYF4 : Yb/Er nanoparticles with FAchitosan conjugates were specific in targeting lung cancer cell lines (H460) rather than human lung fibroblast (HLF) cells. Consequently, the surface chemistry and functional design of the upconverted luminescence nanocrystals using biocompatible FAchitosan conjugates might provide a powerful nanoplatform for the detection and molecular diagnosis of lung cancer.

Graphical abstract: Functionalization of upconverted luminescent NaYF4 : Yb/Er nanocrystals by folic acid–chitosan conjugates for targeted lung cancer cell imaging

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Publication details

The article was received on 21 Dec 2010, accepted on 23 Mar 2011 and first published on 20 Apr 2011


Article type: Paper
DOI: 10.1039/C0JM04468G
J. Mater. Chem., 2011,21, 7661-7667

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    Functionalization of upconverted luminescent NaYF4 : Yb/Er nanocrystals by folic acidchitosan conjugates for targeted lung cancer cell imaging

    Q. Chen, X. Wang, F. Chen, Q. Zhang, B. Dong, H. Yang, G. Liu and Y. Zhu, J. Mater. Chem., 2011, 21, 7661
    DOI: 10.1039/C0JM04468G

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