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Issue 11, 2011
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Facile fabrication of magnetic metal–organic framework nanocomposites for potential targeted drug delivery

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Abstract

In this paper, we describe a facile, efficient, and environmentally friendly fabrication of a novel type of magnetic porous metal–organic-framework (MOF)-based nanocomposites that can be potentially used for targeted drug delivery. The magnetic MOF nanocomposites were fabricated by incorporation of Fe3O4 nanorods with nanocrystals of Cu3(BTC)2 (HKUST-1), a three dimensional (3D) MOF with a 3D channel system. The as-synthesized materials exhibited both magnetic characteristics and high porosity, making them excellent candidates for targeted drug delivery systems. An anti-cancer drug acting as a selective cyclooxygenase-2 (COX-2) inhibitor for pancreatic cancer treatment, Nimesulide, was laden into pores of the nanocomposites. These MOF-based magnetic nanocomposites could adsorb up to 0.2 g of Nimesulide per gram of composite, and it took as long as 11 days to complete the drug release in physiological saline at 37 °C.

Graphical abstract: Facile fabrication of magnetic metal–organic framework nanocomposites for potential targeted drug delivery

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Article information


Submitted
05 Jun 2010
Accepted
06 Dec 2010
First published
28 Jan 2011

J. Mater. Chem., 2011,21, 3843-3848
Article type
Paper

Facile fabrication of magnetic metal–organic framework nanocomposites for potential targeted drug delivery

F. Ke, Y. Yuan, L. Qiu, Y. Shen, A. Xie, J. Zhu, X. Tian and L. Zhang, J. Mater. Chem., 2011, 21, 3843
DOI: 10.1039/C0JM01770A

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