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Issue 5, 2011
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Flow microreactor synthesis of disubstituted pyridines from dibromopyridinesviaBr/Li exchange without using cryogenic conditions

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Abstract

A flow microreactor method for the synthesis of disubstituted pyridines by generation of pyridyllithiums followed by reactions with electrophiles has been developed. By using a short residence time and efficient temperature control, the cryogenic conditions required for conventional batch macro processes can be avoided. Sequential introduction of two different electrophiles into dibromopyridines has been achieved using an integrated flow microreactor system composed of four micromixers and four microtube reactors, to obtain disubstituted pyridine compounds.

Graphical abstract: Flow microreactor synthesis of disubstituted pyridines from dibromopyridinesviaBr/Li exchange without using cryogenic conditions

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Publication details

The article was received on 26 Nov 2010, accepted on 07 Mar 2011 and first published on 28 Mar 2011


Article type: Communication
DOI: 10.1039/C0GC00852D
Green Chem., 2011,13, 1110-1113

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    Flow microreactor synthesis of disubstituted pyridines from dibromopyridinesviaBr/Li exchange without using cryogenic conditions

    A. Nagaki, S. Yamada, M. Doi, Y. Tomida, N. Takabayashi and J. Yoshida, Green Chem., 2011, 13, 1110
    DOI: 10.1039/C0GC00852D

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