Jump to main content
Jump to site search

Issue 8, 2011
Previous Article Next Article

Biocatalytic domino reaction: synthesis of 2H-1-benzopyran-2-one derivatives using alkaline protease from Bacillus licheniformis

Author affiliations

Abstract

A novel BLAP (alkaline protease from Bacillus licheniformis) catalyzed synthesis of 2H-1-benzopyran-2-one derivatives was achieved by domino Knoevenagel/intramolecular transesterification reaction. The control of enzymatic chemoselectivity between Knoevenagel/intramolecular transesterification and Knoevenagel/intramolecular hemiketalization could be realized by adjusting parameters including solvent, water content and temperature. The products were obtained in acceptable yields. This BLAP catalyzed selective domino reaction provided an alternative synthetic method for 2H-1-benzopyran-2-one derivatives.

Graphical abstract: Biocatalytic domino reaction: synthesis of 2H-1-benzopyran-2-one derivatives using alkaline protease from Bacillus licheniformis

Back to tab navigation

Supplementary files

Article information


Submitted
11 Nov 2010
Accepted
03 May 2011
First published
15 Jun 2011

Green Chem., 2011,13, 2048-2054
Article type
Paper

Biocatalytic domino reaction: synthesis of 2H-1-benzopyran-2-one derivatives using alkaline protease from Bacillus licheniformis

C. Wang, Z. Guan and Y. He, Green Chem., 2011, 13, 2048
DOI: 10.1039/C0GC00799D

Social activity

Search articles by author

Spotlight

Advertisements