Issue 11, 2011
From the journal:

Green Chemistry

Efficient and convenient C-3 functionalization of indoles through Ce(OAc)3/TBHP-mediated oxidative C–H bond activation in the presence of β-cyclodextrin

Yu Lin Hu,*a   Hui Jianga  and  Ming Lu*a  

* Corresponding authors

a College of Chemical Engineering, Nanjing University of Science and Technology, Nanjing, P. R. China
E-mail: huyulin1982@163.com, luming1963@163.com
Fax: +86 025-84315030
Tel: +86 025-84315030

Abstract

A simple, green and efficient protocol for the selective C-3 functionalization of indoles with ketones and olefinsviaCe(OAc)3-TBHP mediated oxidative C–H activation in the presence of β-cyclodextrin in water has been developed. This atom-economical protocol affords the target products in good to excellent yields. The products can be separated by a simple extraction with organic solvent, and the catalytic system can be recycled and reused without loss of catalytic activity.

Graphical abstract: Efficient and convenient C-3 functionalization of indoles through Ce(OAc)3/TBHP-mediated oxidative C–H bond activation in the presence of β-cyclodextrin

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Article information

DOI
https://doi.org/10.1039/C1GC15639J
Article type
Communication
Submitted
01 Jun 2011
Accepted
12 Aug 2011
First published
31 Aug 2011

Green Chem., 2011,13, 3079-3087

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Efficient and convenient C-3 functionalization of indoles through Ce(OAc)3/TBHP-mediated oxidative C–H bond activation in the presence of β-cyclodextrin

Y. L. Hu, H. Jiang and M. Lu, Green Chem., 2011, 13, 3079 DOI: 10.1039/C1GC15639J

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