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Issue 1, 2011
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Catalyst-free and catalytic Friedel–Crafts alkylations of indoles in Solkane® 365mfc, an environmentally benign alternative solvent

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Abstract

Solkane® 365mfc is a proven environmentally benign alternative solvent for catalyst-free Friedel–Crafts (F–C) alkylations of indoles with trifluoropyruvate and glyoxylate. Their enantioselective variants are also achieved by virtue of the high-affinity of fluorous cinchona alkaloids catalysts to Solkane® 365mfc to provide F–C adducts in excellent yields with good to excellent ees (up to 96% ee).

Graphical abstract: Catalyst-free and catalytic Friedel–Crafts alkylations of indoles in Solkane® 365mfc, an environmentally benign alternative solvent

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Publication details

The article was received on 29 Sep 2010, accepted on 08 Nov 2010 and first published on 19 Nov 2010


Article type: Communication
DOI: 10.1039/C0GC00619J
Green Chem., 2011,13, 46-50

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    Catalyst-free and catalytic Friedel–Crafts alkylations of indoles in Solkane® 365mfc, an environmentally benign alternative solvent

    X. Xu, A. Kusuda, E. Tokunaga and N. Shibata, Green Chem., 2011, 13, 46
    DOI: 10.1039/C0GC00619J

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