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Issue 7, 2011
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Is iron status associated with highly unsaturated fatty acid status among Canadian Arctic Inuit?

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Abstract

Impaired fatty acid synthesis was noted in iron deficient animal models. Human data, however, are scarce. Although Canadian Inuit have a traditional diet rich in heme iron and long chain n-3fatty acids, recent literature has also indicated the presence of prevalent iron deficiency. We aimed to explore whether the presence of iron deficiency would affect fatty acid status and an estimate of the activity of desaturase 5 (Δ5), which is crucial in the biosynthesis of highly unsaturated n-3fatty acids among Canadian Inuit. Erythrocyte membrane fatty acid composition was utilized as an indicator of fatty acid status and serum ferritin and circulating hemoglobin level were measured as the indicators of iron status. Data analyzed were collected among 1511 Canadian Inuit adult participants in the International Polar Year Inuit Health Survey, 2007–2008. Only 13.7% of survey participants had iron deficiency; however, serum ferritin showed a moderate positive association with highly unsaturated n-3fatty acids after adjusting for age, waist and C-reactive protein (r = 0.172, P < .0001). Serum ferritin correlated significantly with Δ5 after further adjusting for highly unsaturated n-3fatty acids (r = 0.126, P < .0001). Although the current study only demonstrated a weak link between ferritin and Δ5, the latter association underscores a possible health risk caused by a nutrient interaction related to reduced iron intake and decreased highly unsaturated n-3 fatty acid biosynthesis. Future studies are recommended to evaluate iron status in relation to highly unsaturated n-3 fatty acid biosynthesis and status among indigenous people undergoing rapid dietary transitions.

Graphical abstract: Is iron status associated with highly unsaturated fatty acid status among Canadian Arctic Inuit?

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Publication details

The article was received on 30 Mar 2011, accepted on 03 May 2011 and first published on 28 Jun 2011


Article type: Paper
DOI: 10.1039/C1FO10051C
Food Funct., 2011,2, 381-385

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    Is iron status associated with highly unsaturated fatty acid status among Canadian Arctic Inuit?

    Y. E. Zhou, S. Kubow and G. M. Egeland, Food Funct., 2011, 2, 381
    DOI: 10.1039/C1FO10051C

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