Jump to main content
Jump to site search

Issue 2, 2011
Previous Article Next Article

Multistage carcinogenesis process as molecular targets in cancer chemoprevention by epicatechin-3-gallate

Author affiliations

Abstract

The consumption of green tea has long been associated with a reduced risk of cancer development. (−)-Epicatechin-3-gallate (ECG) or (−)-epigallocatechin-3-gallate (EGCG) are the major antioxidative polyphenolic compounds of green tea. They have been shown to exert growth-inhibitory potential of various cancer cells in culture and antitumor activity in vivo models. ECG or EGCG could interact with various molecules like proteins, transcription factors, and enzymes, which block multiple stages of carcinogenesis via regulating intracellular signaling transduction pathways. Moreover, ECG and EGCG possess pharmacological and physiological properties including induction of phase II enzymes, mediation of anti-inflammation response, regulation of cell proliferation and apoptosis effects and prevention of tumor angiogenesis, invasion and metastasis. Numerous review articles have been focused on EGCG, however none have been focused on ECG despite many studies supporting the cancer preventive potential of ECG. To develop ECG as an anticarcinogenic agent, more clear understanding of the cell signaling pathways and the molecular targets responsible for chemopreventive and chemotherapeutic effects are needed. This review summarizes recent research on the ECG-induced cellular signal transduction events which implicate in cancer management.

Graphical abstract: Multistage carcinogenesis process as molecular targets in cancer chemoprevention by epicatechin-3-gallate

Back to tab navigation

Article information


Submitted
06 Dec 2010
Accepted
22 Dec 2010
First published
18 Jan 2011

Food Funct., 2011,2, 101-110
Article type
Review Article

Multistage carcinogenesis process as molecular targets in cancer chemoprevention by epicatechin-3-gallate

M. Pan, Y. Chiou, Y. Wang, C. Ho and J. Lin, Food Funct., 2011, 2, 101
DOI: 10.1039/C0FO00174K

Social activity

Search articles by author

Spotlight

Advertisements