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Volume 152, 2011
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Gold nanoparticle-polymer/biopolymer complexes for protein sensing

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Abstract

Nanoparticle-based sensor arrays have been used to distinguish a wide range of biomolecular targets through pattern recognition. Such biosensors require selective receptors that generate a unique response pattern for each analyte. The tunable surface properties of gold nanoparticles make these systems excellent candidates for the recognition process. Likewise, the metallic core makes these particles fluorescence superquenchers, facilitating transduction of the binding event. In this report we analyze the role of gold nanoparticles as receptors in differentiating a diversity of important human proteins, and the role of the polymer/biopolymer fluorescent probes for transducing the binding event. A structure–activity relationship analysis of both the probes and the nanoparticles is presented, providing direction for the engineering of future sensor systems.

  • This article is part of the themed collection: Gold
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Supplementary files

Article information


Submitted
19 Feb 2011
Accepted
02 Mar 2011
First published
27 Jul 2011

Faraday Discuss., 2011,152, 33-42
Article type
Paper

Gold nanoparticle-polymer/biopolymer complexes for protein sensing

D. F. Moyano, S. Rana, U. H. F. Bunz and V. M. Rotello, Faraday Discuss., 2011, 152, 33
DOI: 10.1039/C1FD00024A

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