Multi-modal molecular imaging approaches to detect primary cells in preclinical models

Kevin Dhaliwal; Lois Alexander; Geraldine Escher; Asier Unciti-Broceta; Maurits Jansen; Neil Mcdonald; Juan M. Cardenas-Maestre; Rosario Sanchez-Martin; John Simpson; Chris Haslett,; Mark Bradley

doi:10.1039/C005410K

Multi-modal molecular imaging approaches to detect primary cells in preclinical models†

Kevin Dhaliwal,*^a Lois Alexander,^b Geraldine Escher,^b Asier Unciti-Broceta,^b Maurits Jansen,^a Neil Mcdonald,^a Juan M. Cardenas-Maestre,^b Rosario Sanchez-Martin,^b John Simpson,^a Chris Haslett,^a and Mark Bradley*^b

Author affiliations

* Corresponding authors

^a MRC Centre for Inflammation Research, Queen's Medical Research Centre, University of Edinburgh, 47 Little France Crescent, Edinburgh, UK
E-mail: kdhaliwa@staffmail.ed.ac.uk

^b School of Chemistry, Joseph Black Building, Kings Buildings, West Mains Road, Edinburgh, UK
E-mail: mark.bradley@ed.ac.uk

Abstract

The need to understand cellular trafficking in vivo in situ requires the development and application of novel methodologies for cellular labeling and cell tracking. Here we applied new technologies associated with advances in molecular imaging to demonstrate the feasibility of labeling primary immune cells. We demonstrate the utility of fluorescently tagged polystyrene microspheres, MRI susceptible emulsions and cell entry peptoids. The adaptation of these labeling agents will permit cell specific delivery, diagnostic sensing and the delivery of therapeutic agents to sites of inflammation and infection.

This article is part of the themed collection: Analysis for Healthcare Diagnostics and Theranostics

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Multi-modal molecular imaging approaches to detect primary cells in preclinical models†

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Multi-modal molecular imaging approaches to detect primary cells in preclinical models

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