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Issue 24, 2011
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Lanthanide complexes as imaging agents anchored on nano-sized particles of boehmite

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Abstract

The synthesis of boehmite nanoparticles modified with lanthanides (Eu, Tb and Gd) is described. Their synthesis, characterization and in vitro assays with HeLa cells were performed. The nuclear magnetic relaxation dispersion (NMRD) profiles of the two chelating moieties were studied. Imaging data from laser scanning confocal fluorescence microscopy and flow cytometry revealed that the nanoscaffolds were taken up by the cells, distributed throughout the cytoplasm and showed no toxicity. This platform could represent an alternative to silica-based inert matrices as imaging vehicles.

Graphical abstract: Lanthanide complexes as imaging agents anchored on nano-sized particles of boehmite

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Publication details

The article was received on 08 Mar 2011, accepted on 08 Apr 2011 and first published on 16 May 2011


Article type: Paper
DOI: 10.1039/C1DT10389J
Dalton Trans., 2011,40, 6451-6457

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    Lanthanide complexes as imaging agents anchored on nano-sized particles of boehmite

    E. Delgado-Pinar, M. T. Albelda, J. C. Frías, O. Barreiro, E. Tejera, V. Kubíček, L. J. Jiménez-Borreguero, F. Sánchez-Madrid, É. Tóth, J. Alarcón and E. García-España, Dalton Trans., 2011, 40, 6451
    DOI: 10.1039/C1DT10389J

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