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Issue 27, 2011
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Metal-containing peptide nucleic acid conjugates

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Peptide Nucleic Acids (PNAs) are non-natural DNA/RNA analogues with favourable physico-chemical properties and promising applications. Discovered nearly 20 years ago, PNAs have recently re-gained quite a lot of attention. In this Perspective article, we discuss the latest advances on the preparation and utilisation of PNA monomers and oligomers containing metal complexes. These metal- conjugates have found applications in various research fields such as in the sequence-specific detection of nucleic acids, in the hydrolysis of nucleic acids and peptides, as radioactive probes or as modulators of PNA˙DNA hybrid stability, and last but not least as probes for molecular and cell biology.

Graphical abstract: Metal-containing peptide nucleic acid conjugates

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Article information

05 Dec 2010
18 Mar 2011
First published
03 May 2011

Dalton Trans., 2011,40, 7061-7076
Article type

Metal-containing peptide nucleic acid conjugates

G. Gasser, A. M. Sosniak and N. Metzler-Nolte, Dalton Trans., 2011, 40, 7061
DOI: 10.1039/C0DT01706J

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