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Issue 5, 2011
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The role of coordination chemistry in the development of copper and rhenium radiopharmaceuticals

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Abstract

There are several isotopes of copper and rhenium that are of interest in the development of new molecular imaging or radiotherapeutic agents. This perspective article highlights the role of coordination chemistry in the design of copper and rhenium radiopharmaceuticals engineered to selectively target tissue of interest such as cancer cells or pathological features associated with Alzheimer's disease. The coordination chemistry of copper bis(thiosemicarbazone) derivatives and copper macrocyclic complexes is discussed in terms of their potential application as targeted positron emission tomography tracers for non-invasive diagnostic imaging. A range of rhenium complexes with different ligands with rhenium in different oxidation states are introduced and their potential to be translated to new radiotherapeutic agents discussed.

Graphical abstract: The role of coordination chemistry in the development of copper and rhenium radiopharmaceuticals

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Article information


Submitted
20 Aug 2010
Accepted
09 Dec 2010
First published
04 Jan 2011

Dalton Trans., 2011,40, 999-1010
Article type
Perspective

The role of coordination chemistry in the development of copper and rhenium radiopharmaceuticals

P. S. Donnelly, Dalton Trans., 2011, 40, 999
DOI: 10.1039/C0DT01075H

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