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Issue 23, 2011
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Biocompatible inorganic nanoparticles for [18F]-fluoride binding with applications in PET imaging

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Abstract

A wide selection of insoluble nanoparticulate metal salts was screened for avid binding of [18F]-fluoride. Hydroxyapatite and aluminium hydroxide nanoparticles showed particularly avid and stable binding of [18F]-fluoride in various biological media. The in vivo behaviour of the [18F]-labelled hydroxyapatite and aluminium hydroxide particles was determined by PET-CT imaging in mice. [18F]-labelled hydroxyapatite was stable in circulation and when trapped in various tissues (lung embolisation, subcutaneous and intramuscular), but accumulation in liver via reticuloendothelial clearance was followed by gradual degradation and release of [18F]-fluoride (over a period of 4 h) which accumulated in bone. [18F]-labelled aluminium hydroxide was also cleared to liver and spleen but degraded slightly even without liver uptake (subcutanenous and intramuscular). Both materials have properties that are an attractive basis for the design of molecular targeted PET imaging agents labelled with 18F.

Graphical abstract: Biocompatible inorganic nanoparticles for [18F]-fluoride binding with applications in PET imaging

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Publication details

The article was received on 21 Nov 2010, accepted on 11 Feb 2011 and first published on 11 Mar 2011


Article type: Paper
DOI: 10.1039/C0DT01618G
Dalton Trans., 2011,40, 6226-6237

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    Biocompatible inorganic nanoparticles for [18F]-fluoride binding with applications in PET imaging

    M. Jauregui-Osoro, P. A. Williamson, A. Glaria, K. Sunassee, P. Charoenphun, M. A. Green, G. E. D. Mullen and P. J. Blower, Dalton Trans., 2011, 40, 6226
    DOI: 10.1039/C0DT01618G

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