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Issue 8, 2011
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Exploring the role of phosphorus substituents on the enantioselectivity of Ru-catalysed ketone hydrogenation using tridentate phosphine-diamine ligands

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Abstract

Methods to produce a range of new phosphine-diamine ligands from phosphino-aldehydes have been developed and a hypothesis that larger P-substituents would increase the enantioselectivity towards the (S) isomer in Ru-catalysed ketone hydrogenation of acetophenone has been examined; the successful validation of this hypothesis is further evidence that the mechanism of these catalysts involves a secondary amine assisted reduction.

Graphical abstract: Exploring the role of phosphorus substituents on the enantioselectivity of Ru-catalysed ketone hydrogenation using tridentate phosphine-diamine ligands

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Publication details

The article was received on 05 Jul 2011, accepted on 15 Aug 2011 and first published on 05 Sep 2011


Article type: Communication
DOI: 10.1039/C1CY00253H
Citation: Catal. Sci. Technol., 2011,1, 1336-1339

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    Exploring the role of phosphorus substituents on the enantioselectivity of Ru-catalysed ketone hydrogenation using tridentate phosphine-diamine ligands

    S. D. Phillips, K. H. O. Andersson, N. Kann, M. T. Kuntz, M. B. France, P. Wawrzyniak and M. L. Clarke, Catal. Sci. Technol., 2011, 1, 1336
    DOI: 10.1039/C1CY00253H

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