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Issue 7, 2011
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Beating cancer in multiple ways using nanogold

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Gold nanoparticles possess a unique combination of properties which allow them to act as highly multifunctional anti-cancer agents (X. H. Huang, P. K. Jain, I. H. El-Sayed and M. A. El-Sayed, Nanomedicine, 2007, 2, 681–693; P. Ghosh, G. Han, M. De, C. K. Kim and V. M. Rotello, Adv. Drug Delivery Rev., 2008, 60, 1307–1315; S. Lal, S. E. Clare and N. J. Halas, Acc. Chem. Res., 2008, 41, 1842–1851; D. A. Giljohann, D. S. Seferos, W. L. Daniel, M. D. Massich, P. C. Patel and C. A. Mirkin, Angew. Chem., Int. Ed., 2010, 49, 3280–3294). Not only can they be used as targeted contrast agents for photothermal cancer therapy, they can serve as scaffolds for increasingly potent cancer drug delivery, as transfection agents for selective gene therapy, and as intrinsic antineoplastic agents. This tutorial review will highlight some of the many forms and recent applications of these gold nanoparticle conjugates by our lab and others, as well as their rational design and physiologic interactions.

Graphical abstract: Beating cancer in multiple ways using nanogold

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Publication details

The article was received on 12 Nov 2010 and first published on 31 May 2011

Article type: Tutorial Review
DOI: 10.1039/C0CS00180E
Chem. Soc. Rev., 2011,40, 3391-3404

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    Beating cancer in multiple ways using nanogold

    E. C. Dreaden, M. A. Mackey, X. Huang, B. Kang and M. A. El-Sayed, Chem. Soc. Rev., 2011, 40, 3391
    DOI: 10.1039/C0CS00180E

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