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Issue 10, 2011
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Decarboxylative coupling reactions: a modern strategy for C–C-bond formation

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Abstract

This critical review examines transition metal-catalyzed decarboxylative couplings that have emerged within recent years as a powerful strategy to form carboncarbon or carbon–heteroatom bonds starting from carboxylic acids. In these reactions, C–C bonds to carboxylate groups are cleaved, and in their place, new carboncarbon bonds are formed. Decarboxylative cross-couplings constitute advantageous alternatives to traditional cross-coupling or addition reactions involving preformed organometallic reagents. Decarboxylative reaction variants are also known for Heck reactions, direct arylation processes, and carbon–heteroatom bond forming reactions.

Graphical abstract: Decarboxylative coupling reactions: a modern strategy for C–C-bond formation

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Article information


Submitted
06 Apr 2011
First published
27 Jul 2011

Chem. Soc. Rev., 2011,40, 5030-5048
Article type
Critical Review

Decarboxylative coupling reactions: a modern strategy for C–C-bond formation

N. Rodríguez and L. J. Goossen, Chem. Soc. Rev., 2011, 40, 5030
DOI: 10.1039/C1CS15093F

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