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Issue 9, 2011
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Towards mild metal-catalyzed C–H bond activation

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Functionalizing traditionally inert carbonhydrogen bonds represents a powerful transformation in organic synthesis, providing new entries to valuable structural motifs and improving the overall synthetic efficiency. C–H bond activation, however, often necessitates harsh reaction conditions that result in functional group incompatibilities and limited substrate scope. An understanding of the reaction mechanism and rational design of experimental conditions have led to significant improvement in both selectivity and applicability. This critical review summarizes and discusses endeavours towards the development of mild C–H activation methods and wishes to trigger more research towards this goal. In addition, we examine select examples in complex natural product synthesis to demonstrate the synthetic utility of mild C–H functionalization (84 references).

Graphical abstract: Towards mild metal-catalyzed C–H bond activation

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Article information

30 Mar 2011
First published
10 Jun 2011

Chem. Soc. Rev., 2011,40, 4740-4761
Article type
Critical Review

Towards mild metal-catalyzed C–H bond activation

J. Wencel-Delord, T. Dröge, F. Liu and F. Glorius, Chem. Soc. Rev., 2011, 40, 4740
DOI: 10.1039/C1CS15083A

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