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Issue 10, 2011
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Recent advances in Sonogashira reactions

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The coupling of aryl or vinyl halides with terminal acetylenes catalysed by palladium and other transition metals, commonly termed as Sonogashira cross-coupling reaction, is one of the most important and widely used sp2–sp carboncarbon bond formation reactions in organic synthesis, frequently employed in the synthesis of natural products, biologically active molecules, heterocycles, molecular electronics, dendrimers and conjugated polymers or nanostructures. This critical review focuses on developments in the Sonogashira reaction achieved in recent years concerning catalysts, reaction conditions and substrates (352 references).

Graphical abstract: Recent advances in Sonogashira reactions

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The article was received on 18 Mar 2011 and first published on 08 Jun 2011

Article type: Critical Review
DOI: 10.1039/C1CS15071E
Chem. Soc. Rev., 2011,40, 5084-5121

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    Recent advances in Sonogashira reactions

    R. Chinchilla and C. Nájera, Chem. Soc. Rev., 2011, 40, 5084
    DOI: 10.1039/C1CS15071E

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